Prolozone Ligament Repair

Prolozone Ligament Repair at Venturis


Prolozone is a form of non-surgical soft tissue and joint therapy used to treat chronic pain. This substance uses ozone gas to repair the connective tissue and body structures. Prolozone involves injections, which heal a joint quickly, relieve tendon/ligament pain, and improve soft tissue functioning.


How does ozone gas work?

Prolozone therapy uses ozone gas, which is a highly reactive molecule. When ozone is injected into the joint capsule or body structure, it can stimulate the fibroblastic repairing abilities of the body. Prolozone is derived from the Latin word “proli,” which means re-build or regenerate.

What is prolozone therapy?

Prolozone is a form of non-surgical ligament reconstruction that is used for chronic pain. By repairing connective tissue, prolozone therapy can actually reverse and stop pain. The doctor injects the ozone gases in the joint to heal it. Sometimes, ultrasound guidance is used to assure correct needle placement. Structures injected include joints, bursa, tendons, ligaments, connective tissue, muscle, and soft tissue.

How does prolozone therapy work?

Pain is persistent when connective tissue in the joint is damaged. Connective tissue can be torn, overly stretched, or scarred. Prolozone injections stimulate tissue repair, tightening of the connective tissue, and joint stabilization. Prolozone therapy involves the injection of ozone into tendons, ligaments, or soft tissues. This causes a localized inflammatory response. When blood flow increases to the damaged area, the tissues receive a flow of nutrients. Prolozone also stimulates anabolic cells, osteoblasts, fibroblasts, and chondroblasts.

How do I prepare for prolozone therapy?

Before you have the injection, you will meet with the pain relief physician for a consultation. You cannot take any anti-inflammatory agents for 48 hours before, during, or after the injection. In addition, no corticosteroids can be taken by mouth or injection during the treatment time. Be sure to tell the doctor about all medicines you take, as certain blood-thinning agents must be held.

What can I expect during the treatment visit?

When you arrive at Venturis Clinic, one of our nurses will have you change into a gown, review the procedure risks and benefits with you, and have you sign a consent form. The area to be injected is cleaned with an antiseptic solution, and the doctor may numb the skin with a local anesthetic. Using real-time x-ray, the procedure needle is inserted into the joint or soft tissue, and the ozone gas is injected. You will have this repeated in 1-2 weeks, most likely.

Who can have prolozone treatments?

Prolozone treatments are used for severe cases of hip arthritis, knee osteoarthritis, tendonitis, bursitis, chronic back pain, disc bulging, sciatica, and soft tissue injuries. You are a candidate if you are in good health, do not have poorly controlled diabetes, and do not have a current infection. The doctor will order some diagnostic imaging tests prior to suggesting prolozone therapy.

Who administers the prolozone injections?

The physician who administers the prolozone therapy is a pain relief professionals, orthopedic surgeon, radiologist, or internist who has been specifically trained in ozone therapy. Our physicians are board-certified with years of clinical experience.

Does prolozone therapy work?

In a study of patients with low back pain secondary to disc herniation, researchers conducted a systematic review of several randomized controlled trials. They were seeking long-term pain relief data (more than 6 months), as well as short-term pain relief efficacy. Ozone therapy was found to yield positive results and very low morbidity rates when used for the treatment of chronic low back pain.


Francisco N, Magalhaes D, Dotta L, (2012). Ozone Therapy as a Treatment for Low Back Pain Secondary to Herniated Disc: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Pain Physician, 15:E115-E12.